Identification of cells expressing a D type G1 cyclin in matured brain: Implication for its role in neuronal function
1993; Elsevier BV; Volume: 153; Issue: 2 Linguagem: Inglês
10.1016/0304-3940(93)90314-b
ISSN1872-7972
AutoresTeruya Tamaru, Surendra Kumar Trigun, Masato Okada, Hachiro Nakagawa,
Tópico(s)Pancreatic function and diabetes
ResumoThe multiple cyclins and their catalytic subunit, cdc2-related kinase, play essential roles in the eucaryotic cell cycle. To examine their potential roles in highly differentiated nervous system, we determined their activity and localization in rat brain. pl3sucl associated histone H1 kinase activity was dramatically increased at the onset of brain maturation. The increased kinase activity was coprecipitated with cyclin D1, a type of G1 cyclin, which also increased with brain maturation. Immunohistochemical analysis demonstrated that anti-cyclin D1-like immunoreactivity was exclusively localized to neurons. From these findings, it is suggested that a type of cdc2-related kinase regulated by cyclin D1 might function in neurons independent of cell cycle progression.
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