Molecular and Cellular Biology of Eosinophil Differentiation Factor (Interleukin‐5) and its Effects on Human and Mouse B Cells
1988; Wiley; Volume: 102; Issue: 1 Linguagem: Inglês
10.1111/j.1600-065x.1988.tb00740.x
ISSN1600-065X
AutoresColin J. Sanderson, Hugh D. Campbell, Ian G. Young,
Tópico(s)Synthesis and Biological Evaluation
ResumoImmunological ReviewsVolume 102, Issue 1 p. 29-50 Molecular and Cellular Biology of Eosinophil Differentiation Factor (Interleukin-5) and its Effects on Human and Mouse B Cells Colin J. Sanderson, Colin J. Sanderson National Institute for Medical Research, The Ridgeway, Mill Hill, London. NW7 1AA, U.K.Search for more papers by this authorHugh D. Campbell, Hugh D. Campbell Medical Molecular Biology Unit, John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia.Search for more papers by this authorIan G. Young, Ian G. Young Medical Molecular Biology Unit, John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia.Search for more papers by this author Colin J. Sanderson, Colin J. Sanderson National Institute for Medical Research, The Ridgeway, Mill Hill, London. NW7 1AA, U.K.Search for more papers by this authorHugh D. Campbell, Hugh D. Campbell Medical Molecular Biology Unit, John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia.Search for more papers by this authorIan G. Young, Ian G. Young Medical Molecular Biology Unit, John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia.Search for more papers by this author First published: April 1988 https://doi.org/10.1111/j.1600-065X.1988.tb00740.xCitations: 184AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Ambrus, J. L., Jurgensen, C. H., Brown, E. J. & Fauci, A. S. (1985) Purification to homogeneity of a high molecular weight human B cell growth factor: demonstration of specific binding to activated B cells; and development of a monoclonal antibody to the factor. J. Exp. Med. 162, 1319. 10.1084/jem.162.4.1319 CASPubMedWeb of Science®Google Scholar Azuma, C, Tanabe, T., Konishi, M., Noma, T., Matsuda, F., Yaoita, Y, Takatsu, K., Hmmerstrom, L., Smith, C. I. E., Severinson, E. & Honjo, T. (1986) Cloning of cDNA for human T cell replacing factor (interleukin-5) and comparison with the murine homologue. Nucleic Acids Res. 14, 9149. 10.1093/nar/14.22.9149 CASPubMedWeb of Science®Google Scholar Barlow, D. P., Bucan, M., Lehrach, H., Hogan, B. L. M. & Gough, N. M. (1987) Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and multi-CSF (IL3). EMBO J. 6, 617. 10.1002/j.1460-2075.1987.tb04799.x CASPubMedWeb of Science®Google Scholar Basten, A. & Beeson, P. B. (1970) Mechanism of eosinophilia. II Role of the lymphocyte. J. Exp. Med. 131, 1288. 10.1084/jem.131.6.1288 PubMedWeb of Science®Google Scholar Begley, C. G., Lopez, A. F., Nicola, N. A., Warren, D. J. & Sanderson, C. J. (1986) Purified colony stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: A rapid and sensitive microassay for colony stimulating factors. Blood 68, 162. 10.1182/blood.V68.1.162.162 CASPubMedWeb of Science®Google Scholar Birnstiel, M. L., Busslinger, M. & Strub, K. (1985) Transcription termination and 3′ processing: the end is in site Cell 41, 349. 10.1016/S0092-8674(85)80007-6 CASPubMedWeb of Science®Google Scholar Butterworth, A. E. (1984) Cell-mediated damage to helminths. Adv. Parasitology 23, 144. Google Scholar Butterworth, A. E., Sturrock, R. F., Houba, V. Mahmoud, A. A. F., Sher, A. & Rees, P. H. (1975) Eosinophils as mediators of antibody dependent damage to schistosomula. Nature 256, 727. 10.1038/256727a0 CASPubMedWeb of Science®Google Scholar Campbell, H. D., Sanderson, C. J., Wang, Y., Hort, Y. Martinson, M. E., Tucker, W. Q. J., Stellwagen, A., Strath, M. & Young, I. G. (1988) Molecular cloning, nucleotide sequence and expression of the gene encoding murine eosinophil differentiation factor. A comparison with other eosinophilopoietic lymphokines and identity with BCGFII (lnterleukin-5). (submitted). Google Scholar Campbell, H. D., Tucker, W. Q. J., Hort, Y., Martinson, M. E., Mayo, G., Clutterbuck, E. J., Sanderson, C. J. & Young, I. G. (1987) Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). Proc. Natl. Acad. Sci. USA 84, 6629. 10.1073/pnas.84.19.6629 CASPubMedWeb of Science®Google Scholar Campbell, H. D., Ymer, S., Fung, M.-C. & Young, I. G. (1985) Cloning and nucleic acid sequence of the murine intertcukin-3 gene. Eur J. Biochem. 150, 297. 10.1111/j.1432-1033.1985.tb09020.x CASPubMedWeb of Science®Google Scholar Clutterbuck, F. J. & Sanderson, C. J. (1988) Human eosinophil production in vitro studied by means of murine eosinophil differentiation factor (IL5). Blood (in press). PubMedWeb of Science®Google Scholar Clutterbuck, E. J., Shields, J., Gordon, J., Smith, S. H., Boyd, A., Callard, R. E., Campbell, H. D, Young, I. G. & Sanderson, C. J. (1987) Recombinant human interleukin-5 (IL5) is an eosinophil differentiation factor but has no activity in standard human B cell growth factor assays. Eur. J. Immunol. 17, 1743. 10.1002/eji.1830171210 CASPubMedWeb of Science®Google Scholar Dao, C. Metcalf, D. & Bilski-Pasquier, G. (1977) Eosinophil and neutrophil colony forming cells in culture. Blood 50, 833. PubMedWeb of Science®Google Scholar Dexter, T. M., Allen, T. D. & Lajtha, L. G. (1977) Conditions controlling the proliferation of haemopoietic stem cells in vitro. J. Cell. Physiol. 91, 335. 10.1002/jcp.1040910303 CASPubMedWeb of Science®Google Scholar Fung, M. C, Hapel, A. J., Ymer, S., Cohen, D. R., Johnson, R. M., Campbell, H. D. & Young, I. G. (1984) Molecular cloning of cDNA for murine interleukin-3. Nature 307, 233. 10.1038/307233a0 CASPubMedWeb of Science®Google Scholar Gleich, G. J. & Adolphson, C. R. (1986) The eosinophilic leukocyte: Structure and function. Adv. Immunology 39, 177. 10.1016/S0065-2776(08)60351-X CASPubMedWeb of Science®Google Scholar Gough, N. M., Gough, J., Metcalf, D., Kelso, A., Grail, D., Nicola, N. A., Burgess, A. W. & Dunn, A. R. (1984) Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor. Nature 309, 763. 10.1038/309763a0 CASPubMedWeb of Science®Google Scholar Gough, N. M., Metcalf, D., Gough, J., Grail, D. & Dunn, A. R. (1985) Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor. EMBO J. 4, 645. 10.1002/j.1460-2075.1985.tb03678.x CASPubMedWeb of Science®Google Scholar Harada, N., Kikuchi, Y., Tominaga, A., Takaki, S. & Takatsu, K. (1985) BCGFII activity on activated B cells of a purified murine T cell replacing factor (TRF) from a T cell hybridoma (B151KI2). J. Immunol. 134, 3944. CASPubMedWeb of Science®Google Scholar Haynes, S. R., Toomey, T. P., Leinwand, L. & Jelinek, W. R. (1981) The Chinese hamster Alu equivalent sequence: a conserved, highly repetitious, interspersed deoxyribonucleic acid sequence in mammals has a structure suggestive of a transposable element. Mol. Cell. Biol. 1, 573. 10.1128/MCB.1.7.573 CASPubMedWeb of Science®Google Scholar Hirano, T. Yasukawa, K., Harada, H., Taga, T., Wanatabe, Y. Matsuda, T. Kashiwamura, S-I. Nakajima, K., Koyama, K., Iwamatsu, A. Tsunasawa, S., Sakiyama, F., Matsui, H., Takahara, Y, Taniguchi, T. & Kishimoto, T. (1986) Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324, 73. 10.1038/324073a0 CASPubMedWeb of Science®Google Scholar Huebner, K., Isobe, M., Croce, C. M., Golde, D. W., Kaufman, S. E. & Gasson, J. C. (1985) The human gene encoding GM-CSF is at 5q21-q32, the chromosome region deleted in the 5q- anomaly. Science 230, 1282. 10.1126/science.2999978 CASPubMedWeb of Science®Google Scholar Hurst, H. C. & Parker, M. G. (1984) Rat prostatic steriod binding protein: characterisation of the Alu element upstream of the C3 genes. AW. Acids Res. 12, 4313. 10.1093/nar/12.10.4313 CASPubMedWeb of Science®Google Scholar Kalb, V. R. Glasser, S., King, D. & Lingrel, J. B. (1983) A cluster of repetitive elements within a 700 base pair region in the mouse genome. AW. Acids Res. 11, 2177. 10.1093/nar/11.7.2177 CASPubMedWeb of Science®Google Scholar Kinashi, T., Harada, N., Severinson, E., Tanabe, T., Sideras, P., Konishi, M., Azuma, C, Tominaga, A., Bergstedt-Lindqvist, S., Takahashi, M., Matsuda, F., Yaoita, Y. Takatsu, K. & Honjo, T. (1986) Cloning of a complementary DNA encoding T-cell Replacing factor and identity with B-cell growth factor II. Nature 324, 70. 10.1038/324070a0 CASPubMedWeb of Science®Google Scholar Kolb, E. & Muller, E. (1979) Local responses in primary and secondary human lung cancers. II. Clinical correlations. Br. J. Cancer 40, 410. 10.1038/bjc.1979.196 CASPubMedWeb of Science®Google Scholar Le Beau, M. M., Epstein, N. D., O'Brien, S. J., Nienhuis, A. W., Yang, Y-C, Clark, S. C. & Rowley, J. D. (1987) The interleukin-3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of5q. Proc. Natl. Acad. Sci. USA 84, 5913. 10.1073/pnas.84.16.5913 CASPubMedWeb of Science®Google Scholar Leff, S. E., Rosenfeld, M. G. & Evans, R. M. (1986) Complex transcriptional units: diversity in gene expression by alternative RNA processing. Ann. Rev. Biochem. 55, 1091. 10.1146/annurev.bi.55.070186.005303 CASPubMedWeb of Science®Google Scholar Lopez, A. F., Begley, C. G., Williamson, D. J., Warren, D. J., Vadas, M. A. & Sanderson, C. J. (1986) Murine eosinophil differentiation factor: An eosinophils-specific colony-stimulating factor with activity for human cells. J. Exp. Med. 163, 1085. 10.1084/jem.163.5.1085 CASPubMedWeb of Science®Google Scholar Lopez, A. F., Bunn Moreno, M. M. & Sanderson, C. J. (1978) The lysis of Trypanosoma cruzi epimastigotes by eosinophils and neutrophils. Int. J. Parasitology 8, 485. 10.1016/0020-7519(78)90069-3 PubMedWeb of Science®Google Scholar Lopez, A. F. & Sanderson, C. J. (1982) Antibody-dependent, cell-mediated cytotoxicity of nucleated mammalian cells by rat eosinophils and neutrophils. Int. Arch. Allergy Appl. Immunol. 67, 200. 10.1159/000233019 CASPubMedWeb of Science®Google Scholar Lopez, A. F., Sanderson, C. J., Gamble, J. R., Campbell, H. D., Young, I. G. & Vadas, M. A. (1987) Recombinant human interleukin-5 (IL-5) is a selective activator of human eosinophil function. J. Exp. Med. 167, 219. 10.1084/jem.167.1.219 PubMedWeb of Science®Google Scholar Lopez, A. F., Strath, M. & Sanderson, C. J. (1981) IgG and complement receptors on purified mouse eosinophils and neutrophils. Immunology 43, 779. CASPubMedWeb of Science®Google Scholar Lopez, A. F., Strath, M. & Sanderson, C. J. (1983) Mouse immunoglobulin isotypes mediating cytotoxicity of target cells by eosinophils and neutrophils. Immunology 48, 503. CASPubMedWeb of Science®Google Scholar Maizel, A. L., Sahasrabuddhe, S., Mehta, S. R., Morgan, L., Lachman, L. & Ford, R. (1982) Biochemical separation of human B cell mitogenic factor. Proc. Natl. Acad. Sci. USA 79, 5998. 10.1073/pnas.79.19.5998 CASPubMedWeb of Science®Google Scholar Matsuo, T., Heller, M., Petti, L., O'Shiro, E. & Kieff, E. (1984) Persistence of the entire Epstein-Barr virus genome integrated into human lymphocyte DNA. Science 226, 1322. 10.1126/science.6095452 CASPubMedWeb of Science®Google Scholar Metcalf, D., Cutler, R. L. & Nicola, N. A. (1983) Selective stimulation by mouse spleen conditioned medium or human eosinophil colony formation. Blood 61, 999. CASPubMedWeb of Science®Google Scholar Metcalf, D., Parker, J. W., Chester, H. M. & Kincade, P. W. (1974) Formation of eosinophilic-like granulocytic colonies by mouse bone marrow cells in vitro. J. Cell. Physiol. 84, 275. 10.1002/jcp.1040840214 CASPubMedWeb of Science®Google Scholar Miyatake, S., Otsuka, T., Yokota, T., Lee, F. & Aria, K. (1985) Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. EMBO J. 4, 2561. 10.1002/j.1460-2075.1985.tb03971.x CASPubMedWeb of Science®Google Scholar Nagata, S., Tsuchiya, M., Asano, S., Yamamoto, T., Hirata, Y. Kubota, N., Oheda, M., Nomura, H. & Yamazaki, T. (1986) The chromosomal gene structure and two mRNA's for human granulocyte colony-stimulating factor. EMBO J. 5, 575. 10.1002/j.1460-2075.1986.tb04249.x CASPubMedWeb of Science®Google Scholar Nicola, N. A., Metcalf, D., Johnson, G. R. & Burgess, A. W. (1979) Separation of functionally distinct human granutocyte-macrophage colony stimulating factors. Blood 54, 614. CASPubMedWeb of Science®Google Scholar Noma, Y., Sideras. P, Naito, T., Bergstedt-Lindquist, S., Azuma, C, Severinson, E., Tanabe, T., Kinashi, T., Matsuda, F., Yaoita, Y & Honjo, T. (1986) Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promotor. Nature 319, 640. 10.1038/319640a0 CASPubMedWeb of Science®Google Scholar O'Garra, A., Warren, D. J., Holman, M., Popham, A. M., Sanderson, C. J. & Klaus, G. B. (1986) Interleukin 4 (B cell growth factor II/eosinophil differentiation factor) is a mitogen and differentiation factor for preactivated murine B lymphocytes. Proc. Natl dead. Sci. USA 83, 5228. 10.1073/pnas.83.14.5228 CASPubMedWeb of Science®Google Scholar Okayama, H. & Berg, P. (1983) A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells. Molec. Cell. Biol. 3, 280. 10.1128/MCB.3.2.280 CASPubMedWeb of Science®Google Scholar Otsuka, T. Villaret, D., Yokota, T. Takebe, Y., Lee, F., Aria, N. & Aria, K. (1987) Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activity. Nucl. Acids Res. 15, 333. 10.1093/nar/15.1.333 CASPubMedWeb of Science®Google Scholar Pretlow, T. P., Kieth, E. F., Cryar, A. K., Bartolueci, A. A., Pitts, A. M. Pretlow, T. G., Kimball, P. M. & Boohaker, E. A. (1983) Eosinophil infiltration of human colonic carcinomas as a prognostic indicator. Cancer Res. 43, 2997. CASPubMedWeb of Science®Google Scholar Sanderson, C. J., Bum Moreno, M. & Lopez, A. F. (1978) Antibody-dependent cell-mediated killing of Trypanosoma cruzi. The release of RNA, DNA and protein. Parasitology 76, 299. 10.1017/S0031182000048174 CASPubMedWeb of Science®Google Scholar Sanderson, C. J. & De Souza, W. (1979) An electron microscopic study of the killing of Trypanosoma cruzi epimastigotes and trypomastigotes by eosinophils and neutrophils. J. Cell Set 37, 275. PubMedWeb of Science®Google Scholar Sanderson, C. J., Lopez, A. F. & Bunn Moreno, M. (1977) Eosinophils and not lymphoid K cells kill Trypanosoma cruzi epimastigotes. Nature 268, 340. 10.1038/268340a0 PubMedWeb of Science®Google Scholar Sanderson, C. J., O'Garra, A., Warren, D. J. &. Klaus, G. G. B. (1986) Eosinophil differentiation factor also has B cell growth factor activity. Proposed name interleukin 4. Proc. Natl. Acad. Sci. USA 83, 437. 10.1073/pnas.83.2.437 CASPubMedWeb of Science®Google Scholar Sanderson, C. J., Strath, M., Warren, D. J., O'Garra, A. & Kirkwood, T. B. L. (1985b) The production of lymphokines by primary alloreactive T cell clones. A co-ordinate analysis of 233 clones in seven lymphokine assays. Immunology 56, 575. CASPubMedWeb of Science®Google Scholar Sanderson, C. J, & Thomas, J. A. (1978) A comparison between the cytotoxic activity of eosinophils and other cells by 51Cr release and time lapse microcinematography. Immunology 34, 771. PubMedWeb of Science®Google Scholar Sanderson, C. J., Warren, D. J. & Strath, M. (1985a) Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to IL3, and functional properties of eosinophils produced in cultures. J. Exp. Med. 162, 60. 10.1084/jem.162.1.60 CASPubMedWeb of Science®Google Scholar Schimpl, A. & Wecker, E. (1975) A third signal in B cell activation by TRF. Transpl. Rev. 23, 176. 10.1111/j.1600-065X.1975.tb00157.x PubMedWeb of Science®Google Scholar Staden, R. (1982) An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences. Nucl. Acids Res. 10, 2951. 10.1093/nar/10.9.2951 CASPubMedWeb of Science®Google Scholar Strath, M., Clutlerbuck, E. J. & Sanderson, C. J. (1988) Production of human and murine eosinophils in vitro and assay for eosinophil differentiation factors. In: Methods in molecular biology. Volume 5. Tissue culture. J. Walker & J. W. Pollard, eds. Clifton , New Jersey Humana Press Inc., (in press). Google Scholar Strath, M. & Sanderson, C. J. (1985) The production and functional properties of eosinophils from bone marrow cultures. J. Cell Sci. 74, 207. CASPubMedWeb of Science®Google Scholar Strath, M. & Sanderson, C. J. (1986) Detection of eosinophil differentiation factor and its relationship to eosinophilia in Mesocestoides corti -infected mice. Exp. Hematol. 14, 16. CASPubMedWeb of Science®Google Scholar Strath, M., Warren, D. J. & Sanderson, C. J. (1985) Detection of eosinophils using an eosinophil peroxidase assay. Us use as an assay for eosinophil differentiation factors. J. Immunol. Methods 83, 209–215. 10.1016/0022-1759(85)90242-X CASPubMedWeb of Science®Google Scholar Sutherland, G. R., Baker, E., Callen, D. F., Campbell, H. D., Young, I. G., Sanderson, C. J., Garson, O. M., Lopez, A. F. & Vadas, M. A. (1987) Interleukin-5 is at 5q31 and is deleted in the 5q− syndrome. Blood (in press). PubMedWeb of Science®Google Scholar Swain, S. & Dutton, R. W. (1982) Production of a B cell growth promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor. J. Exp. Med. 156, 1821. 10.1084/jem.156.6.1821 CASPubMedWeb of Science®Google Scholar Tanno, Y., Bienenstock, J., Richardson, M., Lee, T. D. G., Befus, A. D. & Denburg, J. A. (1987) Reciprocal regulation of human basophil and eosinophil differentiation by separate T cell derived factors. Exp. Hematol. 15, 33. Web of Science®Google Scholar von Heijne, G. (1983) Patterns of amino acids near signal-sequence cleavage sites. Eur. J. Biochem. 133, 17. 10.1111/j.1432-1033.1983.tb07424.x CASPubMedWeb of Science®Google Scholar Warren, D. J. & Sanderson, C. J. (1985) Production of a T cell hybrid producing a lymphokine stimulating eosinophil differentiation. Immunology 54, 615. CASPubMedWeb of Science®Google Scholar Wong, G. G., Temple, P. A., Leary, A. C, Witek-Giannotti, J. S., Yang, Y.-C, Ciarletta, A. B., Chung, M., Murtha, P., Kriz, R., Kaufman, R. J., Ferenz, C. R., Sibley, B. S., Turner, K. J., Hewick, R. M., Clark, S. C, Yanai, N., Yokota, H., Yamada, M., Saito, M., Motoyoshi, K. & Takaku, F. (1987) Human CSF-1: Molecular cloning and expression of 4-kb cDNA encoding the human urinary protein. Science 235, 1504. 10.1126/science.3493529 CASPubMedWeb of Science®Google Scholar Wong, G. G., Witek, J. S., Temple, P. A., Wolkens, K. M., Leary, A. C, Luxenberg, D. P, Jones, S. S., Brown, E. L., Kay, R. M., Orr, E. C. Shoemaker, C, Golde, D. W., Kaufman, R. J., Hewick, R. M., Wang, E. A. & Clark, S. C. (1985) Human GM-CSF: Molecular cloning of the recombinant proteins. Science 228, 810. 10.1126/science.3923623 CASPubMedWeb of Science®Google Scholar Yang, Y.-C, Ciarletta, A. B., Temple, P. A., Chung, M. P., Kovacic, S., Witek-Giannotti, J. S., Leary, A. C, Kriz, R., Donahue, R. E., Wong, G. G. & Clark, S. C. (1986) Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine lL-3. Cell 41, 3. 10.1016/0092-8674(86)90360-0 Web of Science®Google Scholar Yokota, T., Coffman, R. L., Hagiwara, H., Rennick, D. M., Takebe, Y., Yokota, K., Gemmell, L., Shrader, B., Yang, G., Meyerson, P., Luh, J., Hoy, P., Pene, J., Briere, F., Spits, H., Banchereau, J., de Vries, J., Lee, F. D., Aria, N. & Arai, K. (1987) Isolation and characterisation of lymphokine cDNA clones encoding mouse and human IgA enhancing factor and eosinophil colony stimulating factor activities: Relationship to interleukin 5. Proc. Nail. Acad. Sci. USA 84, 7388. 10.1073/pnas.84.21.7388 CASPubMedWeb of Science®Google Scholar Yokota, T. Otsuka, T., Mosmann, T., Banchereau, J., DeFrance, T., Blanchard, D., De Vries, J. E., Lee, F. & Arai, K. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to B cell stimulatory factor 1, that expresses B cell and T cell stimulating activities. Proc. Natl. Acad. Sci. USA 83, 5894. 10.1073/pnas.83.16.5894 CASPubMedWeb of Science®Google Scholar Yoshizaki, K., Nakagawa, T., Fukunaga, K., Tseng, L. T., Yamamura, Y. & Kishimoto, T. (1984) Isolation and characterisation of B cell differentiation factor (BCDF) HCXBtod from a human lymphoblastoid cell line. J. Immunol. 132, 2948. CASPubMedWeb of Science®Google Scholar Citing Literature Volume102, Issue1April 1988Pages 29-50 ReferencesRelatedInformation
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