Colocalization of CA19‐9 and KL‐6 to epithelial cells in dilated bronchioles in a patient with idiopathic pulmonary fibrosis complicated by diffuse alveolar damage
2002; Wiley; Volume: 7; Issue: 3 Linguagem: Inglês
10.1046/j.1440-1843.2002.00391.x
ISSN1440-1843
AutoresYūji Shimizu, Tetsuya Hamada, Yoshiki Tanaka, Atsushi Sasaki, T Nemoto,
Tópico(s)Occupational exposure and asthma
ResumoA 73-year-old woman with idiopathic pulmonary fibrosis (IPF) had an elevated serum CA19-9 level, but not KL-6. Her condition worsened and she subsequently died and this was associated with a rise in the serum KL-6 level. At autopsy, the lung showed a honeycomb appearance macroscopically and, microscopically, hyaline membrane formation was seen. Immunohistochemical staining revealed partial colocalization of KL-6 and CA19-9 to dilated bronchiolar cells. These features suggest that the mechanisms that cause the synthesis and release of CA19-9 and KL-6 from damaged lung tissue in IPF are likely to differ from those in diffuse alveolar damage. In addition, serum KL-6 levels may reflect the severity of disease more sensitively than CA19-9 levels.
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