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Strategies in optical resolution: a practical guide

2008; Elsevier BV; Volume: 19; Issue: 5 Linguagem: Inglês

10.1016/j.tetasy.2008.02.004

1362-511X

Ferenc Faigl, Elemér Fogassy, Mihäly Nógrádi, Emese Pálovics, József Schindler,

Mass Spectrometry Techniques and Applications

Despite the dramatic development of enantioselective synthesis and chromatographic separation methods, resolution still remains the most inexpensive and operationally simplest method for producing pure enantiomers on a large scale. No extreme conditions or expensive reagents are required and the expensive resolving agents can be eventually recovered. This review presents guidelines for selecting the optimal method for resolving a given racemate and is based mainly on the authors long experience in the resolution of industrially important molecules. Methods for predicting the efficiency of the resolution based on the analysis of physico-chemical properties of the reactants are also described.