DIFFERENT SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CIMETIDINE, RANITIDINE HYDROCHLORIDE, AND FAMOTIDINE
2002; Taylor & Francis; Volume: 35; Issue: 4 Linguagem: Inglês
10.1081/sl-120013890
ISSN1532-2289
AutoresKahdiga M. Kelani, Azza Aziz, Maha A. Hegazy, Laila Abdel-Fattah,
Tópico(s)Electrochemical sensors and biosensors
ResumoABSTRACT In this work three different spectrophotometric methods were established for the determination of cimetidine (I), ranitidine hydrochloride (II) and famotidine (III) The first one is a colorimetric method, it was applied for the determination of the three drugs by using sodium nitroprusside as a color reagent to produce a red colored complexes. In this method, the zero order spectrum 0D was used for the determination of drug (III) at λ=500 nm while the first derivative spectra 1D were used for the determination of drug (I) and (II) at their corresponding wave lengths 523 and 510 nm and Δ λ=4 nm. The method can be considered as a stability indicating method for the determination of the three drugs in the presence of their induced hydrogen peroxide oxidative degradates. Beer's law was obeyed in the concentration range of 25–150 µg·mL−1 for (I) and 50–500 µg·mL−1 for (II) and (III) with mean percentage recoveries of 100.27±0.697, 99.79±0.465 and 99.15±0.687, respectively. The second method is a simpl...
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