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ARTHRALGIA, HEADACHE, PROSTRATION, AND FEVER DURING HYDRALAZINE THERAPY

1954; American Medical Association; Volume: 154; Issue: 17 Linguagem: Inglês

10.1001/jama.1954.02940510019008

2376-8118

N. Balfour Slonim,

Pharmacogenetics and Drug Metabolism

The antihypertensive drug hydralazine (Apresoline) is currently in widespread use. It has recently been recognized that the prolonged administration of large doses of hydralazine may give rise to a syndrome including arthalgia, fever, and prostration; however, a detailed description of the clinical course of this syndrome has not yet been presented. The nature of this reaction is obscure, and the question whether its occurrence precludes further use of hydralazine is of considerable practical importance. REPORT OF A CASE The patient, a 48-year-old white married housewife, was first noted to have arterial hypertension at age 27. The first symptoms referable to hypertension were noted at age 39, when she complained of exertional dyspnea, palpitation, and dizziness. These symptoms became progressively worse, and at age 43 she first noted paroxysmal nocturnal dyspnea. Her arterial pressure was then 240/120 mm. Hg. Shortly after this, a rice diet (eight weeks), bed rest, and sedation