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BIBTEX RIS

A Preliminary Controlled Trial of Cognitive Behavioral Therapy in Clozapine-Resistant Schizophrenia

2009; Lippincott Williams & Wilkins; Volume: 197; Issue: 11 Linguagem: Inglês

10.1097/nmd.0b013e3181be7422

1539-736X

Eliza Martha de Paiva Barretto, Mônica Kayo, Belquiz S. Avrichir, Antônio Reis de Sá, Maria das Graças Miquelutti Camargo, Isabel Cristina Napolitano, Fabiano G. Nery, Jony Arrais Pinto, Silvia Bannwart, Silvia Scemes, Elaine Di Sarno, Hélio Elkis,

Mental Health and Psychiatry

The use of cognitive-behavior therapy (CBT) in addition to antipsychotic regimen to treat persistent psychotic symptoms of schizophrenia is growing. The aim of this study was to compare the efficacy of CBT to a befriending (BF) control group in patients with schizophrenia who are refractory to clozapine. Twenty-one patients completed the 21-week trial. In comparison with the control group, the CBT group showed a significant improvement in the General Psychopathology and total score of the Positive and Negative Syndrome Scale, as well as an improvement of Quality of Life scale. The improvement in psychopathology persisted at 6-month follow-up assessment.