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Lipase-catalysed transesterification in the preparation of optically active solketal

1994; Issue: 23 Linguagem: Inglês

10.1039/p19940003459

2050-8255

Eero Vänttinen, Liisa T. Kanerva,

Analytical Chemistry and Chromatography

A lipase-catalysed method for a large-scale preparation of both (R)-(ee 99%) and (S)-solketal (ee 94% after double resolution) has been described. Separation of the reaction products in the resolution mixture was achieved by extraction/distillation and the unwanted enantiomer was racemized and recycled.