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Reticulohistiocytoma and Multicentric Reticulohistiocytosis

1994; Lippincott Williams & Wilkins; Volume: 16; Issue: 6 Linguagem: Inglês

10.1097/00000372-199412000-00001

1533-0311

Bettina G. Zelger, R. Cerio, H. Peter Soyer, K.J. Misch, Guy Orchard, E. WILSON‐JONES,

Tumors and Oncological Cases

The clinicopathological and immunohistochemical features of four patients with systemic multicentric reticulo-histiocytosis (MR) were compared with five cases of solitary and one case of multiple reticulohistiocytoma (RH), which were confined to the skin only. The MR cases mostly affected the limbs of older women, while RH affected young male adults without preference to site. Characteristically, both entities consisted of oncocytic mononuclear histiocytes (with granular eosinophilic cytoplasm similar to oncocytic thyroid cells) and multinucle-ated histiocytes with a ground-glass appearance, which appeared to be much larger (>200 um) and bizarre in cases of RH compared with cases of MR (50–100 μm). In RH a variable number of vacuolated, spindle-shaped, and xanthomatized mononuclear histiocytes were also present. Immunohistochemical profiles showed positivity of mononuclear histiocytes with HHF35, factor XIlla, and LN3 (HLA-DR), with a variable number of multinu-cleated histiocytes in RH showing binding with peanut agglutinin. In mono- and multinucleated histiocytes in both entities macrophage markers KPI (CD68), KiMIP, HAM56, lysozyme, and αl-antitrypsin were positive. However, macrophage markers MAC387 (LI antigen) and Leu-Mi (CD15) were negative. Vimentin was universally positive in both conditions, with all other markers (S100, desmin, smooth muscle-specific actin, and QBEnd 10 [CD34]) negative. This study shows that histology supplemented by immunocytochemistry delineates MR from RH and immunohistochemical profiles indicate a cell lineage relationship between RH and adult xanthogranu-loma.