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Involvement of endogenous digitalis-like substance in genesis of deoxycorticosterone-salt hypertension

1982; Elsevier BV; Volume: 30; Issue: 21 Linguagem: Inglês

10.1016/0024-3205(82)90313-7

1879-0631

Itaru Kojima, Shuko Yoshihara, Etsuro Ogata,

Blood Pressure and Hypertension Studies

In an attempt to evaluate the role of endogenous digitalis-like substance in the genesis of deoxycorticosterone (DOCA) -salt hypertension, the effects of intravenous anti-digoxin antibody on the blood pressure response were observed in male Wistar rats that underwent heminephrectomy followed by treatment with DOCA and saline. Administration of anti-digoxin antibody caused a marked decrease in the blood pressure which continued for about an hour. Such a change in the blood pressure was not observed in pertinent control animals. Thus, it seems that endogenous digitalis-like substance plays an important role in the genesis of DOCA-salt hypertension.