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Total Replacement of Urethral Mucosa with Oral Mucosa in Dogs

1996; Lippincott Williams & Wilkins; Volume: 156; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(01)65913-5

1527-3792

Keiji Iizuka, Osamu Muraishi, Toshitaka Maejima, Yoshihiro Kitami, Yue‐Min Xu, Kenji Watanabe, Akimi Ogawa,

Bladder and Urothelial Cancer Treatments

No AccessJournal of UrologyInvestigative Urology1 Aug 1996Total Replacement of Urethral Mucosa with Oral Mucosa in Dogs Keiji Iizuka, Osamu Muraishi, Toshitaka Maejima, Yoshihiro Kitami, Yue-Min Xu, Kenji Watanabe, and Akimi Ogawa Keiji IizukaKeiji Iizuka More articles by this author , Osamu MuraishiOsamu Muraishi More articles by this author , Toshitaka MaejimaToshitaka Maejima More articles by this author , Yoshihiro KitamiYoshihiro Kitami More articles by this author , Yue-Min XuYue-Min Xu More articles by this author , Kenji WatanabeKenji Watanabe More articles by this author , and Akimi OgawaAkimi Ogawa More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65913-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: If the urethral mucosa is replaced by another mucosa, urethral recurrence might decrease in patients who undergo neobladder construction for bladder cancer. We determined whether such replacement is possible. Materials and Methods: Six dogs underwent an operation consisting of a longitudinal urethral incision at its full length and immediate closure. In 6 other dogs, after the urethral mucosa was totally removed, a tubularized sublingual mucosa was closely set inside the urethral lumen. Postoperatively, the urinary stream and external meatus were observed every day. To measure urine leakage, a 10-minute pad test was performed once a month. All dogs were sacrificed 3 to 12 weeks after the operation for histological examination of the urethra. The excised urethras were examined with a 12F catheter for urethral patency. Results: All dogs were continent postoperatively. The results of the 10-minute pad test showed no significant difference in the weight increase of the pad among the control, sham-operated and mucosa-replaced dogs. Urethral stricture developed in 1 mucosa-replaced dog. Histological examination revealed that all of the grafted oral mucosa survived in the urethra. Conclusion: These results indicate that the urethral mucosa can be replaced by oral mucosa without damaging the continence mechanism in female dogs. References 1 : Neobladder construction using completely detubularized sigmoid colon after radical cystoprostatectomy. J. Urol.1991; 146: 311. Link, Google Scholar 2 : Functional and urodynamic characteristics of bladder substitution with detubularized right colonic segment. Br. J. Urol.1991; 67: 298. Google Scholar 3 : Health-related quality of life after cystectomy: bladder substitution compared with ileal conduit diversion. A questionnaire survey. Br. J. Urol.1995; 75: 200. Google Scholar 4 : 25-year experience with of the human bladder (Camey procedure). J. Urol.1984; 132: 886. Abstract, Google Scholar 5 : Transprostatic selective cystectomy with an ileal bladder. Eur. Urol.1990; 18: 253. Google Scholar 6 : End results in the replacement of mucous membrane of the urinary bladder with thick-split grafts of skin. Surgery1956; 39: 434. Medline, Google Scholar 7 : Urethral injuries in female subjects following pelvic fractures. J. Urol.1992; 147: 139. Link, Google Scholar 8 : Functional replacement of bladder and urethra after cystectomy for bladder cancer in a female patient. J. Urol.1995; 153: 1043. Link, Google Scholar 9 : The buccal mucosal graft for urethral reconstruction: a preliminary report. J. Urol.1992; 147: 662. Link, Google Scholar 10 : Optimization of uretero-intestinal anastomosis in urinary diversion: an experimental study in dogs. I. Evaluation of the Le Duc technique. Urol. Res.1993; 21: 125. Google Scholar Departments of Urology and Pathology, Shinshu University School of Medicine, Matsumoto, Japan.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 156Issue 2August 1996Page: 498-501 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Keiji Iizuka More articles by this author Osamu Muraishi More articles by this author Toshitaka Maejima More articles by this author Yoshihiro Kitami More articles by this author Yue-Min Xu More articles by this author Kenji Watanabe More articles by this author Akimi Ogawa More articles by this author Expand All Advertisement PDF downloadLoading ...