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Dynamics of Ordered Water in Interfacial Enzyme Recognition: Bovine Pancreatic Phospholipase A 2

2003; Wiley; Volume: 43; Issue: 1 Linguagem: Inglês

10.1002/anie.200352961

1521-3773

Liang Zhao, Samir Kumar Pal, Tianbing Xia, Ahmed H. Zewail,

Hemoglobin structure and function

Angewandte Chemie International EditionVolume 43, Issue 1 p. 60-63 Communication Dynamics of Ordered Water in Interfacial Enzyme Recognition: Bovine Pancreatic Phospholipase A2† Liang Zhao, Liang Zhao Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA, Fax: (+1) 626-796-8315Search for more papers by this authorSamir Kumar Pal, Samir Kumar Pal Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA, Fax: (+1) 626-796-8315Search for more papers by this authorTianbing Xia, Tianbing Xia Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA, Fax: (+1) 626-796-8315Search for more papers by this authorAhmed H. Zewail Prof. Dr., Ahmed H. Zewail Prof. Dr. [email protected] Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA, Fax: (+1) 626-796-8315Search for more papers by this author Liang Zhao, Liang Zhao Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA, Fax: (+1) 626-796-8315Search for more papers by this authorSamir Kumar Pal, Samir Kumar Pal Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA, Fax: (+1) 626-796-8315Search for more papers by this authorTianbing Xia, Tianbing Xia Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA, Fax: (+1) 626-796-8315Search for more papers by this authorAhmed H. Zewail Prof. Dr., Ahmed H. Zewail Prof. Dr. [email protected] Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA, Fax: (+1) 626-796-8315Search for more papers by this author First published: 17 December 2003 https://doi.org/10.1002/anie.200352961Citations: 35 † Financial support from the National Science Foundation is acknowledged. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Slippery when wet: Water molecules at the interface between a protein (e.g. bovine pancreatic phospholipase A2) and a micellar substrate act as a lubricant and facilitate movement and binding of the protein at the surface (see picture). Studies of the hydration dynamics before and after complexation reveal that these interactions are crucial for enzymatic function. Citing Literature Volume43, Issue1December 22, 2003Pages 60-63 RelatedInformation