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Structure–function relationships of glutamine synthetases

2000; Elsevier BV; Volume: 1477; Issue: 1-2 Linguagem: Inglês

10.1016/s0167-4838(99)00270-8

1878-1454

David Eisenberg, Harindarpal S. Gill, Gaston M.U. Pfluegl, Sergio H. Rotstein,

Enzyme Structure and Function

As a highly regulated enzyme at the core of nitrogen metabolism, glutamine synthetase has been studied intensively. We review structural and functional studies of both bacterial and eukaryotic glutamine synthetases, with emphasis on enzymatic inhibitors.