A Catalytic Asymmetric Michael Reaction of Silyl Enol Ethers with α,β-Unsaturated Ketones Using a Chiral Titanium Oxide
1994; Oxford University Press; Volume: 23; Issue: 1 Linguagem: Inglês
10.1246/cl.1994.97
ISSN1348-0715
AutoresShū Kobayashi, Shinji Suda, Masaaki Yamada, Teruaki Mukaiyama,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoAbstract In the presence of a catalytic amount of [(R)-1,1′-bi-2-naphthalenediolato(2-)-O,O′]oxotitanium, silyl enol ethers of thioesters reacted with α,β-unsaturated ketones to afford the corresponding Michael adducts (1,5-dicarbonyl compounds) in high yields with moderate to high enantiomeric excesses.
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