Artigo Revisado por pares

Thermal Study of Lysozyme Binding with β-Cyclodextrin

2011; Trans Tech Publications; Volume: 110-116; Linguagem: Inglês

10.4028/www.scientific.net/amm.110-116.1966

ISSN

2297-8941

Autores

Gholamreza Rezaei Behbehani, L. Barzegar,

Tópico(s)

Drug Solubulity and Delivery Systems

Resumo

Effects of β-cyclodextrin, βCD, on refolding of lysozyme was investigated at pH 12 employing isothermal titration calorimetry (ITC) at 300K in 30mM Tris buffer solution. βCD was employed as an anti-aggregation agent and the heats obtained for lysozyme+βCD interactions are reported and analyzed in terms of the extended solvation model. It was indicated that there are two sets of identical and non-cooperative sites for βCD.

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