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IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL STUDY OF RHABDOSPHINCTER COMPONENT OF THE PROSTATIC CAPSULE

1997; Lippincott Williams & Wilkins; Volume: 158; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(01)64138-7

1527-3792

Ahmad Elbadawi, Ranjiv Mathews, J. Keith Light, Thomas M. Wheeler,

Urologic and reproductive health conditions

No AccessJournal of UrologyClinical Urology: Original Articles1 Nov 1997IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL STUDY OF RHABDOSPHINCTER COMPONENT OF THE PROSTATIC CAPSULE Ahmad Elbadawi, Ranjiv Mathews, J. Keith Light, and Thomas M. Wheeler Ahmad ElbadawiAhmad Elbadawi , Ranjiv MathewsRanjiv Mathews , J. Keith LightJ. Keith Light , and Thomas M. WheelerThomas M. Wheeler View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64138-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: There has been no complete agreement on functional anatomy of muscular components of the urethral sphincteric mechanism, particularly in the male patient. The prostatic capsule was studied to define its histological structure and to determine whether its rhabdosphincter component (prostatocapsular rhabdosphincter) consists only of slow twitch or slow and fast twitch striated myofibers. Materials and Methods: We studied 11 whole prostates, including 1 obtained at autopsy and 10 by radical prostatectomy. Samples of prostatic capsule from 4 operative specimens were studied by electron microscopy. Whole mount paraffin sections from transverse slices of the remaining 7 prostates were double labeled with avidin biotin conjugate immunostaining using the primary monoclonal antibodies anti-alpha smooth muscle actin plus anti-alpha sarcomeric actin (all striated myofibers) or antiskeletal myosin fast (fast myofibers only). Tissue components of the prostatic capsule, including smooth muscle and slow versus fast twitch striated myofibers, were quantified by computerized image analysis. Results: The prostatic capsule consisted of collagen, smooth muscle and striated myofibers. It varied in thickness and proportion of the 3 components among specimens, and in each in relation to transverse circumferential aspect and craniocaudal (horizontal) level of the prostate. Collagen and smooth muscle were equally important components. Striated muscle elements within the capsule consisted of fast twitch and dominant slow twitch myofibers, and were much more abundant in the caudal (distal, lower) than the cranial (proximal, upper) half of the capsule, where they were deficient ventrally (anteriorly) and dorsally (posteriorly). The prostatocapsular rhabdosphincter thus had a butterfly-like appearance, with a thick posteriorly open ring at the apex and 2 thinner, divergent leaflets tapering toward the base at the bladder neck. The fast myofiber population decreased progressively from apex to base of prostate. Conclusions: Proof is provided for mixed slow and fast twitch myofiber structure of the prostatocapsular component of human male rhabdosphincter. Sustained (tonic) contraction of slow myofibers probably reinforces the role of urethral smooth muscle in maintaining continence during bladder filling. 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Link, Google Scholar From the Departments of Pathology and Urology, State University of New York, Health Science Center, Syracuse, New York, and Department of Pathology, Baylor College of Medicine, Houston, Texas.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byStafford R, Ashton-Miller J, Constantinou C and Hodges P (2018) Novel Insight into the Dynamics of Male Pelvic Floor Contractions Through Transperineal Ultrasound ImagingJournal of Urology, VOL. 188, NO. 4, (1224-1230), Online publication date: 1-Oct-2012.Koraitim M (2018) The Male Urethral Sphincter Complex Revisited: An Anatomical Concept and its Physiological CorrelateJournal of Urology, VOL. 179, NO. 5, (1683-1689), Online publication date: 1-May-2008.MATHEWS R, GOSLING J and GEARHART J (2018) ULTRASTRUCTURE OF THE BLADDER IN CLASSIC EXSTROPHY: CORRELATION WITH DEVELOPMENT OF CONTINENCEJournal of Urology, VOL. 172, NO. 4 Part 1, (1446-1449), Online publication date: 1-Oct-2004.MYERS R, CAHILL D, KAY P, CAMP J, DEVINE R, KING B and ENGEN D (2018) PUBOPERINEALES: MUSCULAR BOUNDARIES OF THE MALE UROGENITAL HIATUS IN 3D FROM MAGNETIC RESONANCE IMAGINGJournal of Urology, VOL. 164, NO. 4, (1412-1415), Online publication date: 1-Oct-2000.DORSCHNER W, BIESOLD M, SCHMIDT F and STOLZENBURG J (2018) THE DISPUTE ABOUT THE EXTERNAL SPHINCTER AND THE UROGENITAL DIAPHRAGMJournal of Urology, VOL. 162, NO. 6, (1942-1945), Online publication date: 1-Dec-1999.MATHEWS R, WILLS M, PERLMAN E and GEARHART J (2018) NEURAL INNERVATION OF THE NEWBORN EXSTROPHIC BLADDER: AN IMMUNOHISTOCHEMICAL STUDYJournal of Urology, VOL. 162, NO. 2, (506-508), Online publication date: 1-Aug-1999.BURNETT A and MOSTWIN J (2018) IN SITU ANATOMICAL STUDY OF THE MALE URETHRAL SPHINCTERIC COMPLEX: RELEVANCE TO CONTINENCE PRESERVATION FOLLOWING MAJOR PELVIC SURGERYJournal of Urology, VOL. 160, NO. 4, (1301-1306), Online publication date: 1-Oct-1998. Volume 158Issue 5November 1997Page: 1819-1828 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Ahmad Elbadawi More articles by this author Ranjiv Mathews More articles by this author J. Keith Light More articles by this author Thomas M. Wheeler More articles by this author Expand All Advertisement PDF downloadLoading ...