Hybrids of macrolides and nucleobases or nucleosides
2000; Elsevier BV; Volume: 41; Issue: 18 Linguagem: Inglês
10.1016/s0040-4039(00)00417-2
ISSN1873-3581
AutoresAnna M. Costa, Jaume Vilarrasa,
Tópico(s)Biochemical and Molecular Research
ResumoA few examples of hybrids/conjugates/chimeras of erythromycin A derivatives and nucleobases (uracil and thymine) or thymidine-derived nucleosides are reported. Linkers and reaction conditions have been investigated to avoid the degradation of the macrolide moiety (glycoside hydrolysis, ring cleavage, dehydration, etc.).
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