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Efficacy of various drugs in the prevention of posterior capsule opacification: Experimental study of rabbit eyes

2004; Lippincott Williams & Wilkins; Volume: 30; Issue: 12 Linguagem: Inglês

10.1016/j.jcrs.2004.05.013

1873-4502

Viviana Fernández, Miryam A. Fragoso, C Billotte, P. Lamar, M. Orozco, Sander Dubovy, Mark Willcox, Jean–Marie Parel,

Traumatic Ocular and Foreign Body Injuries

In Brief Purpose: To assess the efficacy of various drugs in the prevention of posterior capsule opacification (PCO) in a closed capsular bag technique. Setting: Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA. Methods: Lens material was removed using phacoaspiration or phacoemulsification through a microcapsulorhexis according to the hardness of the crystalline lens correlated with the weight and age of the rabbits. A mixture of an ophthalmic viscosurgical device (sodium hyaluronate 1.4% [SHA]) and a drug was injected into the empty capsular bag, allowed to remain inside for 3 minutes, and removed. The capsular bag was rinsed with balanced salt solution (BSS®) and refilled with SHA. In a group of rabbits, the capsulorhexis was sealed with a minicapsulorhexis valve (MCV). Rabbits were treated with 1 of the following: SHA (control), BSS, mitomycin-C (MMC, 0.2 mg/mL), ethylenediaminetetraacetic acid (EDTA) (10 mM and 15 mM), 5-fluorouracil (5-FU, 33 mg/mL), acetic acid (3%, 0.3%, and 0.003%), and distilled water. Results: Upon completion of the study, the control and treated eyes had PCO and new lens material (not residual). Anterior capsule proliferation was observed in eyes treated with 5-FU. The order of PCO appearance (earliest to latest) was as follows: 15 mM EDTA, SHA, MMC, acetic acid 0.3%, acetic acid 3%, BSS, distilled water (small animals; no MCV), acetic acid 0.003%, 5-FU, 10 mM EDTA, and distilled water (large animals; MCV). The earliest appearance was day 1 postoperatively and the latest, day 47. Conclusions: Distilled water and 10 mM EDTA treatments were the most efficient in retarding the appearance of PCO. Efficacy of various drugs in the prevention of PCO was assessed. A delay in the appearance of PCO in treated eyes ranged from 1 day to 47 days postoperatively.