Portal de Periódicos da CAPES

Relative Dominance of Gag p24-Specific Cytotoxic T Lymphocytes Is Associated with Human Immunodeficiency Virus Control

2006; American Society for Microbiology; Volume: 80; Issue: 6 Linguagem: Inglês

10.1128/jvi.80.6.3122-3125.2006

1098-5514

Rosario Zuñiga, Aldo Lucchetti, Patricia Galván, Shyla Sanchez, Carmen Nibot Sánchez, Ana González Hernández, Hugo Sánchez, Nicole Frahm, Caitlyn Linde, Hannah S. Hewitt, William H. Hildebrand, Marcus Altfeld, Todd M. Allen, Bruce D. Walker, Bette Korber, Thomas Leitner, Jorge Sánchez, Christian Brander,

Immunotherapy and Immune Responses

Conflicting data on the role of total virus- and protein-specific cytotoxic-T-lymphocyte (CTL) responses in the control of human immunodeficiency virus (HIV) disease progression exist. We present data generated from a Peruvian cohort of untreated, clade B-infected subjects, demonstrating that the proportion of Gag-specific, and in particular p24-reactive, CTL responses among the total virus-specific CTL activity is associated with individuals' CD4 counts and viral loads. Analyses in a second cohort in the United States confirm these findings and point towards a dominant role of Gag-specific immunity in effective control of HIV infection, providing important guidance for HIV vaccine development.