Produção Nacional
Revisado por pares
Mast cell concentration and skin wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi)
2015; Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia; Volume: 30; Issue: 4 Linguagem: Inglês
10.1590/s0102-865020150040000008
ISSN1678-2674
AutoresLígia Reis de Moura Estevão, Juliana Pinto de Medeiros, Ricardo Santos Simões, Rosa Maria Esteves Arantes, Milene Alvarenga Rachid, Regildo Márcio Gonçalves da Silva, Fábio de Souza Mendonça, Joaquim Evêncio‐Neto,
Tópico(s)Contact Dermatitis and Allergies
ResumoPURPOSE: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with 5% BPT essential oil-based ointment in rats. METHODS: Twenty rats, male, of adult age, were submitted to skin surgery on the right (RA) and left antimeres (LA) of the thoracic region. They were divided into two groups: control (RA - wounds receiving daily topical application of vaseline and lanolin) and treated (LA - wounds treated daily with the topical ointment). The skin region with wounds were collected at days 4, 7, 14 and 21 after surgery. Those were fixed in 10% formaldehyde and later processed for paraffin embedding. Sections were obtained and stained by H.E for histopathology analysis. The degree of epithelial contraction was measured and mast cell concentration were also evaluated. RESULTS: The treated group showed higher mast cell concentrations (p<0.05) associated with increased contraction at day 7 and 14 respectively. CONCLUSION: Ointment containing 5% Brazilian pepper tree oil increases mast cell concentration and promotes skin wound contraction in rats.
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