PhI(OAc) 2 -Mediated Synthesis of 6-(Trifluoromethyl)phenanthridines by Oxidative Cyclization of 2-Isocyanobiphenyls with CF 3 SiMe 3 under Metal-Free Conditions
2013; American Chemical Society; Volume: 15; Issue: 18 Linguagem: Inglês
10.1021/ol4022589
ISSN1523-7060
AutoresQile Wang, Xichang Dong, Tiebo Xiao, Lei Zhou,
Tópico(s)Cyclopropane Reaction Mechanisms
ResumoA mild and efficient method for the synthesis of 6-(trifluoromethyl)phenanthridines through oxidative cyclization of 2-isocyanobiphenyls with CF3SiMe3 under metal-free conditions was developed. The reaction allows the direct formation of C-CF3 bonds and rapid access to phenanthridine ring systems in one catalytic cycle.
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