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Ischemic neurons recruit natural killer cells that accelerate brain infarction

2014; National Academy of Sciences; Volume: 111; Issue: 7 Linguagem: Inglês

10.1073/pnas.1315943111

1091-6490

Yan Gan, Qiang Liu, Wei Wu, Junxiang Yin, Xue‐Feng Bai, Rulong Shen, Yongjun Wang, Jieli Chen, Antonio La Cava, Jennifer Poursine‐Laurent, Wayne M. Yokoyama, Fu‐Dong Shi,

Immune cells in cancer

Significance Stroke is a devastating illness second only to cardiac ischemia as a cause of death worldwide. Long-time attempts to salvage dying neurons and preserve neurological functions via various neuroprotective agents have failed, owing at least in part to medical science’s limited knowledge of ischemia-induced elements that participate in irreversible neurovascular damage. The present study was performed to understand the role of natural killer (NK) cells, a key member of the innate immune system, in stroke. We discovered that NK cells infiltrated the brains of stroke patients and mice with induced stroke. Multiple pathways by which NK cells exacerbate brain infarction are discovered. This study revealed the role of NK cells in the pathogenesis of stroke.