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Palladium-Catalyzed Carbonylative Cross-Coupling with Imines: A Multicomponent Synthesis of Imidazolones

2007; American Chemical Society; Volume: 73; Issue: 3 Linguagem: Inglês

10.1021/jo701875b

1520-6904

Ali R. Siamaki, D. A. Black, Bruce A. Arndtsen,

Synthesis of Indole Derivatives

The palladium-catalyzed coupling of imines, chloroformates, organotin reagents, and carbon monoxide leads to the one-pot formation of ketocarbamates in good yields. These products can further be converted to highly substituted imidazolones via a cyclocondensation reaction. Overall, this methodology provides an alternative approach to imidazolones from five simple and readily available building blocks via a one-pot, multicomponent process.