The enzymic synthesis of the sulfate esters of estradiol-17β and diethylstilbesterol
1963; Elsevier BV; Volume: 71; Linguagem: Inglês
10.1016/0006-3002(63)91146-6
ISSN1878-2434
Autores Tópico(s)Steroid Chemistry and Biochemistry
ResumoThe present study demonstrates the formation of three sulfate esters of estradiol and three of diethylstilbesterol by a microsome-free extract of rat liver. The sulfate esters were separated by paper chromatography using a potassium phosphate buffer solvent and detected by radioautography using 35S. Evidence is presented that the three sulfate esters of estradiol are estradiol-3-sulfate, estradiol-17-sulfate and estradiol-3,17-disulfate and that those of diethylstilbesterol are two isomeric monosulfate esters and the disulfate ester of diethylstilbesterol.
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