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HYPERSENSITIVENESS TO ARSPHENAMINE IN GUINEA-PIGS

1929; American Medical Association; Volume: 20; Issue: 5 Linguagem: Inglês

10.1001/archderm.1929.01440050079007

2376-3760

Marion B. Sulzberger,

Effects and risks of endocrine disrupting chemicals

In a recent paper W. Frei 1 reported that he had been able to sensitize the skin of guinea-pigs by means of a single intradermal injection of a small quantity of neoarsphenamine. This sensitization could be demonstrated later by the changed reaction of the skin to a second injection of the same substance. Although some other successful sensitizations of animals to chemically defined substances have been reported in the literature, the experiments of Frei offer a skin hypersensitivity in animals which fulfils an unusually large number of the requirements for experimental research. To my mind, they give a method of investigating processes of hypersensitivity which embodies the following advantages: 1. The substance employed is one which plays an important rôle in conditions of hypersensitivity in human beings (arsphenamine dermatitides) which have already been studied both clinically and experimentally (Klauder, 2 Kagelmann, 3 Biberstein, 4 Frei and Mayer, 5 Frei, 6