Desensitizing GABAC receptors on carp retinal bipolar cells
1997; Lippincott Williams & Wilkins; Volume: 8; Issue: 6 Linguagem: Inglês
10.1097/00001756-199704140-00003
ISSN1473-558X
AutoresMing‐Hu Han, Ying Li, Xiong-Li Yang,
Tópico(s)Ion channel regulation and function
ResumoBICUCULLINE and baclofen-insensitive GABA receptors (GABAC receptors) on bipolar cells acutely dissociated from carp retina were investigated with using the whole-cell patch-clamp recording technique. The currents of these cells mediated by GABAC receptors showed striking desensitization, even at low concentrations of GABA. Both the time constant τ of the GABAC current decay and the extent of desensitization were significantly different from that of GABAC receptors previously observed in other retinas and elsewhere in the CNS, suggesting that the GABAC receptors of carp bipolar cells might be distinct in intracellular mechanisms and subunit composition.
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