Polyneuropathy: an unusual extraintestinal manifestation of Crohn's disease
1989; Wiley; Volume: 80; Issue: 4 Linguagem: Inglês
10.1111/j.1600-0404.1989.tb03883.x
ISSN1600-0404
AutoresP Humbert, G. Monnier, C Billerey, C Birgen, J.L. Dupond,
Tópico(s)Gastrointestinal motility and disorders
ResumoActa Neurologica ScandinavicaVolume 80, Issue 4 p. 301-306 Polyneuropathy: an unusual extraintestinal manifestation of Crohn's disease P. Humbert, Corresponding Author P. Humbert Departments of Internal Medicine and Clinical Immunology, Besancon, FrancePhillipe Humbert Department of Internal Medicine and Clinical Immunology Centre Hospitalier Universitaire Jean Minjoz 25030 Besancon Cedex FranceSearch for more papers by this authorG. Monnier, G. Monnier Departments of Electrophysiology and Histopathology, Centre Hospitalier Universitaire Jean Minjoz, Besancon, FranceSearch for more papers by this authorC. Billerey, C. Billerey Departments of Histopathology, Centre Hospitalier Universitaire Jean Minjoz, Besancon, FranceSearch for more papers by this authorC. Birgen, C. Birgen Departments of Internal Medicine and Clinical Immunology, Besancon, FranceSearch for more papers by this authorJ. L. Dupond, J. L. Dupond Departments of Internal Medicine and Clinical Immunology, Besancon, FranceSearch for more papers by this author P. Humbert, Corresponding Author P. Humbert Departments of Internal Medicine and Clinical Immunology, Besancon, FrancePhillipe Humbert Department of Internal Medicine and Clinical Immunology Centre Hospitalier Universitaire Jean Minjoz 25030 Besancon Cedex FranceSearch for more papers by this authorG. Monnier, G. Monnier Departments of Electrophysiology and Histopathology, Centre Hospitalier Universitaire Jean Minjoz, Besancon, FranceSearch for more papers by this authorC. Billerey, C. Billerey Departments of Histopathology, Centre Hospitalier Universitaire Jean Minjoz, Besancon, FranceSearch for more papers by this authorC. Birgen, C. Birgen Departments of Internal Medicine and Clinical Immunology, Besancon, FranceSearch for more papers by this authorJ. L. Dupond, J. L. Dupond Departments of Internal Medicine and Clinical Immunology, Besancon, FranceSearch for more papers by this author First published: October 1989 https://doi.org/10.1111/j.1600-0404.1989.tb03883.xCitations: 13AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract ABSTRACT— Among the extraintestinal complications of Crohn's disease, neuropathy seems to be rare, and is only exceptionally reported in the literature. The authors present the report of a patient followed over a 12-year period who developed polyneuropathy with a parallel course to Crohn's disease. There was no evidence of any other underlying condition. On one occasion, the patient developed a cutaneous vasculitis with fibrinoid deposits in the vessels. The search for circulating immune complexes was positive. The authors demonstrated increased intestinal permeability using the 51chromium-labeled ethylenediaminetetra-acetate (51Cr-EDTA) test. Ultrastructural study of a biopsy of the superficial peroneal nerve disclosed a marked denervation process. Therapeutic plasmapheris were performed, improving the neurologic symptoms. Vasculitis with circulating immune complexes is suggested as a possible mechanism in view of the occurrence of cutaneous vasculitis, increased intestinal permeability, and plasma exchange efficiency. Citing Literature Volume80, Issue4October 1989Pages 301-306 RelatedInformation
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