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Hepatotoxicity Caused by Metronidazole Overdose

1995; American College of Physicians; Volume: 122; Issue: 10 Linguagem: Inglês

10.7326/0003-4819-122-10-199505150-00023

1539-3704

Sing Lam,

Metabolism and Genetic Disorders

Letters15 May 1995Hepatotoxicity Caused by Metronidazole OverdoseSing Lam and Simmy BankSing LamLong Island Jewish Medical Center, New Hyde Park, NY 11040.Search for more papers by this author and Simmy BankLong Island Jewish Medical Center, New Hyde Park, NY 11040.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-10-199505150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The most frequently reported adverse effects of metronidazole include gastrointestinal symptoms such as nausea, vomiting, metallic taste, abdominal discomfort, and diarrhea. More serious side effects include reversible peripheral neuropathy, convulsions, and blood dyscrasias [1]. To our knowledge, only one suspected case of metronidazole-induced hepatotoxicity has been reported in the English-language literature [2].We recently encountered a patient who developed drug-induced hepatitis caused by metronidazole overdose. A 58-year-old-woman was hospitalized in October 1994 because of dizziness and fainting. Her medical history included chronic depressive illness. She also had chronic low-back pain and insomnia. She had had lumbosacral laminectomy ...References1. Goldman P. Metronidazole. N Engl J Med. 1980; 303:212-8. Google Scholar2. Appleby DH, Vogyland HD. Suspected metronidazole hepatotoxicity. Clin Pharmacol. 1983; 2:373-4. Google Scholar3. Brogden RN, Heel RC, Speigt TM. Metronidazole in anaerobic infections: a review of its activity, pharmacokinetics and therapeutic use. Drugs. 1978; 16:387-417. Google Scholar Author, Article, and Disclosure InformationAuthors: Sing Lam; Simmy BankAffiliations: Long Island Jewish Medical Center, New Hyde Park, NY 11040. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug‐Induced Liver DiseaseSevere hepatotoxicity associated with the combination of spiramycin plus metronidazoleOrnidazole-induced liver damage: report of three cases and review of the literatureNitroimidazole-induced chronic hepatitisMetronidazole and Darkened Urine: Is There a Causal Relationship?Metronidazole overdose 15 May 1995Volume 122, Issue 10Page: 803KeywordsAbscessesAntidepressantsDrugsHepatitis ALiverNauseaSyncopeTasteTricyclic antidepressantsVomiting ePublished: 15 August 2000 Issue Published: 15 May 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...