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Interleukin-10 and Interleukin-12 Modulation in Patients with Relapsing-Remitting Multiple Sclerosis on Therapy with Interferon-beta 1a: Differences in Responders and Non Responders

2008; Taylor & Francis; Volume: 30; Issue: 4 Linguagem: Inglês

10.1080/08923970802302753

1532-2513

P Carrieri, Paolo Ladogana, Gaetano Di Spigna, Maria Fulvia de Leva, Maria Petracca, Silvana Montella, Luigi Buonavolontà, Ciro Florio, Loredana Postiglione,

Immunotherapy and Immune Responses

AbstractWe examined the effects of interferon (IFN)beta-1a on interleukin (IL)-12p70 and IL-10 secretion in 27 Relapsing Remitting Multiple Sclerosis (RRMS) patients, divided in responders and non-responders. In responders, IFNbeta-1a does not change the IL-12p70 concentrations, but it leads to a remarkable increase in the IL-10 production. Besides, a high IL-10/IL-12 ratio is demonstrated during the first six months of therapy. In non-responders, there were not significant alterations in the cytokine profile. We suggest that IFNbeta-1a effect in RRMS patients could be explained by its modifying effect on cytokine pattern. Moreover, we propose a possible role of IL-10/ IL-12 ratio as a serum marker predictive of favorable clinical course.Keywords: Multiple SclerosisCytokinesInterferon-Beta