Seasonal influenza vaccine delivered by intradermal microinjection: A randomised controlled safety and immunogenicity trial in adults
2008; Elsevier BV; Volume: 26; Issue: 51 Linguagem: Inglês
10.1016/j.vaccine.2008.09.078
ISSN1873-2518
AutoresIsabel Leroux–Roels, Eva Vets, Ralf Freese, Michael Seiberling, Françoise Weber, Camille Salamand, Geert Leroux‐Roels,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoInfluenza vaccines remain largely underused. A promising alternative to current intramuscular vaccines is a trivalent inactivated influenza vaccine (TIV) delivered using a microinjection system to offer a less invasive and possibly more acceptable vaccination. A phase II, multicentre, randomised open-label study in 978 healthy adults (18-57 years) evaluated the immunogenicity and safety of intradermal TIV. Subjects received a 0.1 ml injection of intradermal TIV, containing 9 microg of haemagglutinin (HA) per strain (n = 588) or a conventional 0.5 ml intramuscular vaccine (15 microg of HA/strain; n = 390). Intradermal TIV induced non-inferior humoral immune responses against all three strains and superior responses against both A strains (H1N1, H3N2) compared with the control. Both vaccines were well tolerated.
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