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Regulation of ornithine decarboxylase synthesis effect of a nutritional deficiency of vitamin B6

1974; Elsevier BV; Volume: 14; Issue: 5 Linguagem: Inglês

10.1016/0024-3205(74)90087-3

1879-0631

John A. Sturman, Leon T. Kremzner,

Metabolism and Genetic Disorders

In vitamin B6 deficiency there is an increase in the activity of the pyridoxal phosphate dependent enzyme ornithine decarboxylase. In the rat liver: the apoenzyme and holoenzyme activity increased 1.6 and 4 fold respectively. Concomitantly, putrescine and spermidine concentrations were halved. The lack of correspondence between product concentration and enzymic activity suggests a control mechanism other than ornithine decarboxylase activity.