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Elevated 1,25-dihydroxyvitamin D serum concentrations in infants with subcutaneous fat necrosis

1993; Elsevier BV; Volume: 122; Issue: 3 Linguagem: Inglês

10.1016/s0022-3476(05)83441-9

1097-6833

K. Kruse, U. Irle, R. Uhlig,

Parvovirus B19 Infection Studies

Two infants with subcutaneous fat necrosis had hypercalcemia that normalized during glucocorticoid treatment. The combination of hypercalcemia, normal concentration of 25-hydroxyvitamin D, an elevated concentration of 1,25-dihydroxyvitamin D, a suppressed parathyroid hormone level, and low-normal bone turnover indicated abnormal 1,25-dihydroxyvitamin D production with increased intestinal absorption of calcium. Unregulated production of 1,25-dihydroxyvitamin D by the granulomatous cells of fat necrosis may cause hypercalcemia.