Portal de Periódicos da CAPES

The natural xanthone α-mangostin reduces oxidative damage in rat brain tissue

2009; Taylor & Francis; Volume: 12; Issue: 1 Linguagem: Inglês

10.1179/147683009x388850

1476-8305

Berenice Márquez‐Valadez, Rafael Lugo-Huitrón, Verónica Valdivia-Cerda, Luis Rubén Miranda-Ramírez, Verónica Pérez de la Cruz, Octavio González-Cuahutencos, Isabel Rivero‐Cruz, Rachel Mata, Abel Santamarı́a, José Pedraza‐Chaverrí,

Biological Activity of Diterpenoids and Biflavonoids

The antiperoxidative properties of α-mangostin, a xanthone isolated from mangosteen fruit, were tested for the first time in nerve tissue exposed to different toxic insults. Two reliable biological preparations (rat brain homogenates and synaptosomal P2 fractions) were exposed to the toxic actions of a free radical generator (ferrous sulfate), an excitotoxic agent (quinolinate), and a mitochondrial toxin (3-nitropropionate). α-Mangostin decreased the lipoperoxidative action of FeSO4 in both preparations in a concentration-dependent manner, and completely abolished the peroxidative effects of quinolinate, 3-nitropropionate and FeSO4 + quinolinate at all concentrations tested. Interestingly, when tested alone in brain homogenates, α-mangostin significantly decreased the lipoperoxidation even below basal levels. α-Mangostin also prevented the decreased reductant capacity of mitochondria in synaptosomal fractions. Our results suggest that α-mangostin exerts a robust antiperoxidative effect in brain tissue preparations probably through its properties as a free radical scavenger. In light of these findings, this antioxidant should be tested in other neurotoxic models involving oxidative stress.