Evolution of Helicobacter pylori primary resistance to clarithromycin in two urban centers in portugal
2001; Elsevier BV; Volume: 120; Issue: 5 Linguagem: Inglês
10.1016/s0016-5085(08)82943-5
ISSN1528-0012
AutoresManuel T. Rosario, Joaquim A. Machado-Caetano, Maria Ana Pessanha, Albertus Bouw, Eduarda Maria Duarte Rodrigues, Manuel T. Rosario,
Tópico(s)Gastric Cancer Management and Outcomes
Resumo79-90%), 75.6% (61-86%), and 72.8% (67-79%) (p<O.01 when comparing duodenal ulcer vs. NUD).Twelve-day regimen was more effective than 6-day regimen only in NUD (62% vs. 83%, p<O.01), but not in duodenal or gastric ulcer.In the multivariate analysis the duration (6 vs. 12 days) of eradication therapy (odds ratio, OR, 2.2; 1.3-3.7)and the type of disease (duodenal ulcer vs. NUD; OR, 2.3; 1.3-3.8)were the only variables which influenced on H.pylori eradication efficacy (chi-square model, 17; p<O.O01).CONCLUSION: Efficacy with omeprazole-amoxicillin-clarithromycin regimen in patients with duodenal ulcer is higher than in those patients with NUD.The increase of H. pylori eradication rate by 21% in our NUD patients justifies the prolongation from 6 to 12 days of omeprazole-amoxicillin-clarithromycin therapy, whilst the increase of cure rates in duodenal or gastric ulcer patients with a 12-day therapy would not be cost-effective. 3002
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