Enhanced Immunogenicity to Mycobacterium tuberculosis by Vaccination with an Alphavirus Plasmid Replicon Expressing Antigen 85A
2002; American Society for Microbiology; Volume: 71; Issue: 1 Linguagem: Inglês
10.1128/iai.71.1.575-579.2003
ISSN1098-5522
AutoresJoanna R. Kirman, Tara N. Turon, Hua Su, Amy Li, Carl N. Kraus, John M. Polo, John T. Belisle, Sheldon L. Morris, Robert A. Seder,
Tópico(s)Viral gastroenteritis research and epidemiology
ResumoThe immunogenicity of a plasmid DNA vaccine incorporating Sindbis virus RNA replicase functions (pSINCP) and expressing antigen 85A (Ag85A) from Mycobacterium tuberculosis was compared with a conventional plasmid DNA vector encoding Ag85A. pSINCP-85A was highly immunogenic in mice and gave enhanced long-term protection against M. tuberculosis compared with the conventional vector.
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