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Semisynthetic peptide–lipase conjugates for improved biotransformations

2012; Royal Society of Chemistry; Volume: 48; Issue: 72 Linguagem: Inglês

10.1039/c2cc34816k

1364-548X

Oscar Romero, Marco Filice, Blanca de las Rivas, César Carrasco‐López, Javier Klett, Antonio Morreale, J.A. Hermoso, José M. Guisán, Olga Abián, José M. Palomo,

Enzyme Catalysis and Immobilization

An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.