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Comparison of MAX-ACT and K-ACT Values When Using Bivalirudin Anticoagulation During Minimally Invasive Hybrid Off-Pump Coronary Artery Bypass Graft Surgery

2011; Elsevier BV; Volume: 25; Issue: 3 Linguagem: Inglês

10.1053/j.jvca.2010.12.007

1532-8422

Philip M. Jones, Daniel Bainbridge, Wojciech B. Dobkowski, Christopher Harle, John M. Murkin, Philip Fernandes, Bob Kiaii,

Venous Thromboembolism Diagnosis and Management

Objective To compare the kaolin-activated coagulation time (K-ACT) to the MAX-ACT for monitoring anticoagulation with bivalirudin in patients undergoing hybrid off-pump coronary artery revascularization procedures. Design A prospective, observational study. Setting A cardiac surgical operating room of a university-affiliated hospital. Participants Twelve patients undergoing off-pump coronary artery bypass graft surgery and percutaneous coronary intervention during the same procedure anticoagulated with bivalirudin to a target K-ACT of >300 seconds. Intervention At baseline and at frequent intervals during anticoagulation, K-ACT and MAX-ACT assays were run contemporaneously, and the pairs of results were analyzed with descriptive statistics, by correlation analysis, and with Bland-Altman analysis. Measurements and Main Results The MAX-ACT and K-ACT assays were highly correlated, but the MAX-ACT assay consistently reported significantly lower ACT values compared with the K-ACT. The mean bias (K-ACT minus MAX-ACT) was 94 seconds (limits of agreement, 51-138 seconds). Conclusion To maximize patient safety, centers using bivalirudin for anticoagulation during cardiac surgical procedures need to be aware of the different performance characteristics of ACT assay subtypes.