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Inhibition of Preadipocyte Differentiation by Germacranolides from Calea urticifolia in 3T3-L1 Cells

2005; Oxford University Press; Volume: 69; Issue: 12 Linguagem: Inglês

10.1271/bbb.69.2470

1347-6947

Nobuyasu Matsuura, Masashi Yamada, Hiroto Suzuki, Naoko Hasegawa, Chihiro Kurosaka, Makoto Ubukata, Toshiyuki Tanaka, Munekazu Iinuma,

Adipokines, Inflammation, and Metabolic Diseases

The effects of germacranolides isolated from Calea urticifolia on adipocytic differentiation of 3T3-L1 cells were examined. These germacranolides inhibited adipogenesis at a concentration of 1.25-5 microM. But no inhibitory activity against cell proliferation and no nonspecific binding activity to protein were observed. These results indicate that these germacranolides are the specific inhibitors of preadipocyte differentiation.