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Globulixanthones A and B, Two New Cytotoxic Xanthones with Isoprenoid Groups from the Root Bark of Symphonia globulifera

2002; American Chemical Society; Volume: 65; Issue: 5 Linguagem: Inglês

10.1021/np010478w

1520-6025

Augustin E. Nkengfack, Pierre Mkounga, Zacharias T. Fomum, Michèle Meyer, Bernard Bodo,

Plant and Biological Electrophysiology Studies

Bioassay-guided fractionation of a root bark extract of Symphonia globulifera has yielded, in addition to stigmasterol, two new xanthones with isoprenoid units, named globulixanthones A (1) and B (2). The structures of these compounds have been elucidated by spectroscopic means. They possess significant cytotoxicity in vitro against the KB cell line.