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Are varicoceles associated with increased deoxyribonucleic acid fragmentation?

2011; Elsevier BV; Volume: 96; Issue: 6 Linguagem: Inglês

10.1016/j.fertnstert.2011.10.016

1556-5653

Armand Zini, Gert R. Dohle,

Selenium in Biological Systems

The exact pathophysiologic effect of varicocele on male fertility potential is not known. Recent studies have shown that varicocele is associated with sperm DNA damage, and this sperm pathology may be secondary to varicocele-mediated oxidative stress. The beneficial effect of varicocelectomy on sperm DNA damage further supports the premise that varicocele may impair sperm DNA integrity. However, larger, well-designed studies are needed to better define the relationship between varicocele and sperm DNA damage.