Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-α production in murine macrophages
1999; Elsevier BV; Volume: 21; Issue: 7 Linguagem: Inglês
10.1016/s0192-0561(99)00024-7
ISSN1879-3495
Autores Tópico(s)Bioactive natural compounds
ResumoHigh amounts of nitric oxide and TNF-alpha generated by activated macrophages induce several pathophysiological conditions during acute and chronic inflammation. Identification of new pharmacological reagents that can prevent TNF-alpha and/or NO overproduction is of considerable medical interest. In this report we provide evidence that the overproduction of TNF-alpha and NO by LPS stimulated macrophages can be markedly inhibited by quercetin, a major active component of plant Rhododendron cinnabarium.
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