Anxiety in the rat is associated with decreased release of 5-HT and glycine from the hippocampus
1987; Elsevier BV; Volume: 83; Issue: 3 Linguagem: Inglês
10.1016/0304-3940(87)90107-8
ISSN1872-7972
AutoresSandra E. File, Peter F. Curle, Helen A. Baldwin, Michael J. Neal,
Tópico(s)Memory and Neural Mechanisms
ResumoRats, implanted with dialysis loops in the dorsal hippocampus, were injected with subconvulsant doses of pentylenetetrazole (PTZ 15 and 30 mg/kg) and a 30-min sample collected for high-performance liquid chromatography (HPLC) analysis of amines and amino acids. Immediately after the sampling period they were given a 5-min test in the elevated plus-maze. On the basis of their performance in this test, they were divided into an 'anxious' and a 'non-anxious' group. The anxious group had significantly lower levels of glycine and serotonin (5-HT) release. Although PTZ decreased the release of noradrenaline, this was not correlated with behavioural differences in the elevated plus-maze.
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