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Patterns of antibodies to hepatitis C virus and hepatitis C virus replication in children with chronic non-A, non-B hepatitis

1994; Elsevier BV; Volume: 125; Issue: 6 Linguagem: Inglês

10.1016/s0022-3476(05)82009-8

1097-6833

Flavia Bortolotti, Pietro Vajro, C. Barbera, Cinzia Crivellaro, Lucia Zancan, R. Giacchino, Gabriella Nebbia, Loredana Lepore, Emanuele Barbierato, Lorena De Moliner, D. Cavalletto, A. Albertí,

Liver Disease Diagnosis and Treatment

Antibodies to hepatitis C virus (HCV), investigated by second- and third-generation assays, were detected in 74% of 43 children with chronic non-A, non-B hepatitis. The polymerase chain reaction identified HCV ribonucleic acid in 26 (93%) of 28 seropositive and in 1 of 10 seronegative cases. Intermittent HCV ribonucleic acid positivity, suggesting low and fluctuating viremia, was frequent in younger patients.