Micellar interaction of indomethacin and bile salts
1981; Elsevier BV; Volume: 8; Issue: 4 Linguagem: Inglês
10.1016/0378-5173(81)90070-3
ISSN1873-3476
AutoresShôzô Miyazaki, TOMOHIRO YAMAHIRA, Yasunori Morimoto, TANEKAZU NADAI,
Tópico(s)Analytical Chemistry and Chromatography
ResumoIn the previous report, it was confirmed that bue salt micelles display a significantly higher affinity for indomethacin as compared to phenylbutazone in pH 7.3 phosphate buffer at 37°C. The extent of micellar solubilization seemed to be influenced by the nature of the solubilized molecule. The difference between indomethacin and phenylbutazone in micellar interaction was investigated. This difference could not be explained on the basis of the lipid solubility and molal volume. It was suggested that the mechanism responsible for the solubilization of indomethacin may be due to the formation of mixed micelles of the bile salts and the drug. On the other hand, the lower of interaction of phenylbutazone with bile salt micelles can probably be attributed to its carbon acid.
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