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MITOMASTER: a bioinformatics tool for the analysis of mitochondrial DNA sequences

2008; Wiley; Volume: 30; Issue: 1 Linguagem: Inglês

10.1002/humu.20801

1098-1004

Marty C. Brandon, Eduardo Ruiz‐Pesini, Dan Mishmar, Vincent Procaccio, Marie T. Lott, Kevin Cuong Nguyen, Syawal Spolim, Upen Patil, Pierre Baldi, Douglas C. Wallace,

Metabolism and Genetic Disorders

We have developed a computer system, MITOMASTER, to make analysis of human mitochondrial DNA (mtDNA) sequences efficient, accurate, and easily available. From imported sequences, the system identifies nucleotide variants, determines the haplogroup, rules out possible pseudogene contamination, identifies novel DNA sequence variants, and evaluates the potential biological significance of each variant. This system should be beneficial for mtDNA analyses of biomedical physicians and investigators, population biologists and forensic scientists. MITOMASTER can be accessed at http://mammag.web.uci.edu/twiki/bin/view/Mitomaster. Hum Mutat 0,1–6, 2008. © 2008 Wiley-Liss, Inc.