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Blockade of 5-HTP reduction of ethanol drinking with the decarboxylase inhibitor, Ro 4-4602

1981; Elsevier BV; Volume: 15; Issue: 6 Linguagem: Inglês

10.1016/0091-3057(81)90045-9

1873-5177

Irving Geller, Roy J. Hartmann, F.S. Messiha,

Receptor Mechanisms and Signaling

5-Hydroxytryptophan (5-HTP) reduced ethanol intake in laboratory rats. The reduction of ethanol intake was blocked when Ro 4-4602, the decarboxylase inhibitor, was given in combination with the 5-hydroxytryptophan. These observations provide further support for the involvement of brain serotonin in voluntary ethanol drinking by the rat.