Streptozocin-induced diabetes decreases formation of prostacyclin from arachidonic acid in intact rat lungs
1982; Academic Press; Volume: 28; Issue: 3 Linguagem: Inglês
10.1016/0006-2944(82)90082-5
ISSN1557-7996
AutoresWilliam C. Lubawy, Monica Valentovic,
Tópico(s)Eicosanoids and Hypertension Pharmacology
ResumoAbstract Diminished vascular prostacyclin (PGI 2 ), as well as elevated platelet thromboxane (TXA 2 ) generation is known to occur in diabetes and may be involved in the thrombotic and atherosclerotic complications of this disease. Pulmonary tissue synthesizes both PGI 2 and TXA 2 ; however, alterations in the generation of these substances in diabetic lungs has not been reported. We determined PGI 2 and TXA 2 generation from 14 C arachidonic acid in isolated perfused lungs obtained from male rats 1 and 14 days after a 50 mg/kg i.v. dose of streptozocin or the citrate-buffer vehicle. Compared to controls, lungs from rats made diabetic for 14 days showed a 30% decrease in PGI 2 generation with no change in TXA 2 . A direct inverse relationship of pulmonary PGI 2 TXA 2 ratios to plasma glucose levels for the 14-day diabetic rats occurred ( r 2 = −0.886). The 1-day study showed no difference between control and diabetic rats which suggests that alterations in arachidonic acid metabolism observed after 14 days are the result of the diabetic condition and not streptozocin. These data indicate that pulmonary PGI 2 synthesis is altered by diabetes of short duration in a manner similar to vascular tissue.
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