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BIBTEX RIS

Effect of tones, footshocks, shuttle avoidance, and electroconvulsive shock on met-encephalin immunoreactivity of rat brain

1982; Academic Press; Volume: 34; Issue: 1 Linguagem: Inglês

10.1016/s0163-1047(82)91371-1

ISSN

1557-8003

Autores

María A. Carrasco, Marcos L. S. Perry, Renato Dutra Dias, Susana Tchernin Wofchuk, Iván Izquierdo,

Tópico(s)

Stress Responses and Cortisol

Resumo

Met-encephalin immunoreactivity is measured in the amygdala, hypothalamus, and rest of the brain of rats submitted to a 25-min session of 50 footshocks (1.0 mA, 2 sec, 60 Hz), or 50 tones (1 kHz, 5 sec, 70 db), or 50 tone-footshock shuttle-avoidance trials; or sacrificed 10 or 30 min after ECS (15.0 mA, 2 sec, transcorneal). Footshock stimulation and electroconvulsive shock (ECS) cause a reduction of Met-encephalin immunoreactivity in the amygdala and hypothalamus, attributable to release and subsequent degradation of the substance. The other treatments have no effect. The data are consistent with hypotheses that relate endogenous Met-encephalin to pain and/or stress, and with a previously advanced speculation that the amnesic effect of ECS might be mediated by endogenous opioid peptide release.

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