Effect of vitamis A, C and glutathione on the mutagenicity of benzo[a]pyrene mediated by S9 from vitamin A-deficient rats
1987; Elsevier BV; Volume: 192; Issue: 4 Linguagem: Inglês
10.1016/0165-7992(87)90061-3
ISSN1878-7053
AutoresPhilippe Alzieu, Pierrette Cassand, Céline Colin, Pascal Grolier, J.F. Narbonne,
Tópico(s)Antioxidant Activity and Oxidative Stress
ResumoVitamin A deficiency has been shown to enhance the mutagenicity of benzo[a]pyrene (Narbonne et al., 1985). Here we report that this is not a result of increased benzo[a]pyrene metabolism but might be a consequence of either a lack of vitamin A or a decreased level of scavengers (ascorbic acid and glutathione) in the liver. However, the addition of vitamin A in vitro in the form of retinyl palmitate strongly inhibits the benzo[a]pyrene mutagenicity. An enhancing effect on the mutagenicity of benzo[a]pyrene is observed with addition of ascorbic acid when incubated with high amounts of the precarcinogen. In vivo addition of high levels of glutathione also reduces the mutagenicity of benzo[a]pyrene.
Referência(s)