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Energy-resolved mass spectrometry: a comparison of quadrupole cell and cone-voltage collision-induced dissociation

1999; Wiley; Volume: 13; Issue: 16 Linguagem: Inglês

10.1002/(sici)1097-0231(19990830)13

1097-0231

Alex G. Harrison,

Analytical Chemistry and Chromatography

Collision-induced dissociation (CID) can be effected in the interface region between atmospheric pressure ionization sources and single quadrupole mass analyzers. By varying the electric field in these cone-voltage CID experiments energy-resolved mass spectra can be obtained leading to breakdown graphs exploring the energy evolution of the fragmentation pathways. The breakdown graphs obtained from these cone-voltage CID studies are very comparable to those obtained by varying the collision energy in the quadrupole collision cell of a BEqQ mass spectrometer. The comparison has been made for the protonated peptides H-Leu-Gly-Gly-OH, H-Gly-Leu-Gly-OH, H-Gly-Gly-Leu-OH and Leu-enkephalin Copyright © 1999 John Wiley & Sons, Ltd.